However, approximately 20–30% of patients with non-Hodgkin lymphomas and 15% with Hodgkin lymphomas (HL) eventually fail to achieve a complete remission or experience relapse after first-line therapy. Remission status and age at ASCT, and the number of infused stem cells were of prognostic relevance.įrontline immunochemotherapies induce complete remissions in the majority of patients with aggressive B-cell lymphomas. In conclusion, high-dose chemotherapy followed by ASCT in the era of novel targeted agents remains a feasible and effective approach for patients with high-risk or relapsed aggressive B-cell lymphomas. Deaths after ASCT were predominantly caused by lymphoma relapse and/or progression (64%) or due to infections (23%). For patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL), early relapse (< 12 months) after first-line therapy showed a trend towards an inferior PFS and OS. Patients with mantle cell lymphoma (MCL) or primary CNS lymphoma (PCNSL) treated with ASCT in first-line had a superior OS and PFS when compared to patients treated with ASCT in relapsed disease. Multivariate analysis identified remission status at ASCT, age at ASCT, and the numbers of infused CD34 + cells as independent prognostic factors for both PFS and OS. The cumulative incidence of non-relapse mortality at day 100 after ASCT was 4%. After ASCT, 28% of all patients experienced a relapse. Progression-free survival (PFS) and overall survival (OS) after 3 years was 63% and 68%, respectively. The median follow-up of surviving patients was 36 months (range 0–163). Two hundred forty-seven patients with aggressive B-cell lymphomas treated with high-dose chemotherapy and ASCT, either as consolidation after first-line therapy or after salvage therapy for relapsed disease, between 20 at the University Hospital Muenster, were analyzed. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) can induce durable remissions in these patients and is potentially curative. Patients with high-risk or relapsed aggressive B-cell lymphomas are characterized by poor prognosis.
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Brew/Drain switch must be at Brew position.Try the following tips to troubleshoot a Keurig B145 OfficePro brewer that will not brew: Keurig B145 OfficePro brewer will not brew If the brewer is cold/frozen, wait for two hours for it to reach room temperature before powering on.Make sure Brew/Drain switch is at Brew position.You need to prime the brewer for use by filling the internal hot water tank before the first brew.If your Keurig B145 OfficePro brewer doesn’t brew when using it for the first time, try these troubleshooting tips: Keurig B145 OfficePro will not brew when used for the first time Use low temperature cycles in the dishwasher. The k-cup pack holder assembly can be placed onto the top shelf of a dishwasher.Insert a paper clip into the Needle to loosen the clog, then flash with water.Remove the k-cup pack holder assembly and detach funnel.How to Clean the Exit Needle on Keurig 155įollow these instructions to clean exit need on your Keurig brewer: If “OFF” isn’t displayed, you need to reset. “OFF” should be displayed for Auto Off timer and On/Off.To do this, press the MENU button below “MENU” and scroll through the programming options.
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Original character designs have been specially drawn for this event. The event is set to run from July 14 to October. New details for the Attack on Titan and Tobu Zoo collaborative event which was announced last month have been released. ©Hajime Isayama・Kodansha / “Attack on Titan” Production Team *Tickets on sale from Octoat 10:00am (JST) Standing Block A / Reserved Seating A – ¥9,300 (Tax Included) Standing Block S / Reserved Seating S – ¥12,000 (Tax Included) Venue: Makuhari Messe International Exhibition Hall – Halls 9-11 Venue: Tokyo International Forum – Hall A YOSHIKI CLASSICAL 2018 ~Murasaki ni Somatta Yoru~ YOSHIKI with Philharmonic Orchestra Venue: Makuhari Messe International Exhibition Hall – Halls 1-3 X JAPAN Live ~Kurenai ni Somatta Yoru~ Makuhari Messe 3Days Release Date: Octo(worldwide digital download to be available on the same day)
Her time was spent alternating between her Devonshire home, her grandmother's house in Ealing, West London, and parts of Southern Europe, where her family would holiday during the winter. Many of her books and short stories have been filmed, and many have been adapted for television, radio, video games and comics.īorn to a wealthy upper-middle-class family in Torquay, Devon, Christie would describe her childhood as "very happy" and was surrounded by a series of strong and independent women from an early age. In 1955, Christie was the first recipient of the Mystery Writers of America's highest honour, the Grand Master Award, and in the same year Witness for the Prosecution was given an Edgar Award by the MWA for Best Play. In 1971, she was made a Dame by Queen Elizabeth II at Buckingham Palace.Ĭhristie's stage play The Mousetrap holds the record for the longest initial run: it opened at the Ambassadors Theatre in London on 25 November 1952 and as of 2012 was still running after more than 25,000 performances. And Then There Were None is Christie's best-selling novel with 100 million sales to date, making it the world's best-selling mystery ever, and one of the best-selling books of all time. According to Index Translationum, Christie is the most translated individual author, and her books have been translated into at least 103 languages. Her novels have sold roughly four billion copies, and her estate claims that her works rank third, after those of William Shakespeare and the Bible, as the world's most widely published books. She also wrote the world's longest-running play The Mousetrap.Īccording to the Guinness Book of World Records, Christie is the best-selling novelist of all time. She also wrote six romances under the name Mary Westmacott, but she is best remembered for the 66 detective novels and more than 15 short story collections she wrote under her own name, most of which revolve around the investigations of such characters as Hercule Poirot, Miss Jane Marple and Tommy and Tuppence. Awards-Edgar Award and the Grand Master Awardĭame Agatha Mary Clarissa Christie, DBE was a British crime writer of novels, short stories, and plays. Education-home schooled and fininshing school. |
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